Your molecule.Designed fororomucosal delivery.
- 01Sublingual administrationA fine mist is delivered beneath the tongue
- 02Mucosal retentionDesigned to increase the amount of time the formulation remains in contact with the mucosal surface
- 03Permeation supportFormulation strategies are designed to support movement across the oral epithelium
- 04Molecular stabilizationControlled formulation conditions can be tailored to help maintain active-ingredient integrity
Sublingual anatomy — thin mucosal tissue with a rich underlying blood supply provides an alternative pathway for oromucosal delivery.
From molecule assessment
to finished formulation.
Different molecules present different delivery challenges. PermeaPulse™ formulations can be developed around molecular characteristics, concentration, stability, pH, permeability profile, residence time, and intended administration site.
Molecule Assessment
Evaluate molecular characteristics, concentration, stability, permeability, and administration requirements before formulation development.
Formulation Development
Develop a molecule-specific environment around retention, permeability, pH, stability, and the intended administration site.
Scientific Characterization
Finished formulations are evaluated using appropriate analytical and pharmacokinetic studies.
Scale-Up
Translate the optimized formulation towards consistent finished-product production and commercial development.
Performance that is
measured.
Oromucosal administration does not automatically produce systemic exposure equivalent to injection or other established delivery routes. Absorption can vary depending on the molecule, formulation, and individual physiology.
- Absorption
- Bioavailability
- Time to Peak Concentration
- Maximum Concentration
- Overall Systemic Exposure
- Duration of Exposure
Pharmacokinetic studies can be used to scientifically characterize the performance of individual formulations.
Why the same active ingredient works better under the tongue.
A swallowed pill has to survive the stomach before it can work. PermeaPulse absorbs directly through the lining of the mouth, so more of the active ingredient gets where it needs to go.
Four things happen at the surface of the mouth.
Purpose-built. Science-driven. Designed for advanced drug delivery.
Designed to increase the amount of time a formulation remains in contact with the mucosal surface.
Designed to support movement of active molecules across the oral barrier.
Helps maintain the integrity of the active ingredient throughout formulation, storage, and administration.
Supports the integrity and usability of multi-dose finished products.
Where the molecule enters changes everything.
PermeaPulse is built around the oral mucosa, the tissues of the mouth that offer an alternative to the digestive route.
Built per molecule. Measured individually.
Molecular size, structure, stability, and permeability all affect whether a molecule suits oromucosal delivery. Each formulation is developed around the molecule, then its performance is measured.
Oromucosal administration does not automatically match injection or other established routes, and absorption varies by molecule, formulation, and individual physiology. Finished formulations are evaluated individually.
What does "under the tongue" actually do?
How is this different from injecting?
Does every active ingredient work with the technology?
How do you know it works?
Is it safe?
Can it be used for compounding pharmacies?
Built into your product line.
This technology was designed specifically for pharmaceutical companies, labs and pharmacies. Available wholesale for use in your own product line.
Tell us about the active ingredient you are developing.
Our team can begin by reviewing the molecule, target concentration, intended administration route, and formulation requirements.